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师资队伍
孙秀霞
职务/职称:副教授
研 究 所:药剂学研究所
联系电话:
电子邮件:sxx@lzu.edu.cn
办 公 室:杏林楼605室
  • 个人简介
  • 研究成果
  • 研究项目
  • 【基本情况】

        孙秀霞,女,汉族,1989年8月生。2013年获菏泽学院学士学位,2016年获兰州大学硕士学位,2019年获兰州大学博士学位。2019年-2021年在兰州大学从事博士后研究工作。2022年获聘为兰州大学副教授。

    【研究方向】

        设计和筛选可以靶向识别重要蛋白质生物标记物的荧光多肽探针,实现高特异性、高灵敏的体液检测,并探索其在疾病诊断中的应用;

        构建序列精密调控的自组装多肽体系,来仿生细胞外基质的结构和功能,拓展其在组织工程和再生医学中的应用;

        开发蛋白质的制备和交联技术,研发高生物相容性的下一代医用材料。

    【主讲课程】

    【获奖情况】

     

  •     1)Xiuxia Sun, Wenhua Li, Jianxi Xiao*, et al. Ln3+-triggered self-assembly of a heterotrimer collagen mimetic peptide into luminescent nanofibers. Chemical Communications. 2020, 56, 15141-15144. (Cover paper)

        2)Xiuxia Sun, Yan Qiao, Jianxi Xiao*, et al. A graphene oxide-aided triple helical aggregation-induced emission biosensor for highly specific detection of charged collagen peptide. Journal of Materials Chemistry B. 2020, 8, 6027-6033. (Cover paper)

        3)Xiuxia Sun, Zhao Liu, Jianxi Xiao*, et al. A self-assembling collagen mimetic peptide system to simultaneously characterize the effects of osteogenesis imperfecta mutations on conformation, assembly and activity. Journal of Materials Chemistry B. 2019, 7, 3201-3209. (Cover paper)

        4)Xiuxia Sun, Linyan Yao, Jianxi Xiao*, et al. Detection of target collagen peptides with single amino acid mutation using two fluorescent peptide probes. Journal of Materials Chemistry B. 2019, 7, 7676-7682. (Cover paper)

        5)Xiuxia Sun, Manman He, Jianxi Xiao*, et al. Luminescent Biofunctional Collagen Mimetic Nanobers. ACS Omega. 2019, 4, 16270-16279.

        6)Xiuxia Sun, Jun Fan, Jianxi Xiao*, et al. WS2 and MoS2 biosensing platforms using peptides as probe biomolecules. Scientific Reports. 2017, 7, 10290.

        7)Xiuxia Sun, Jun Fan, Jianxi Xiao*, et al. Fluorescence characterization of the thermal stability of collagen mimic peptides. Chinese Chemical Letters. 2017, 28, 963-967.

        8)Xiuxia Sun, Jun Fan, Jianxi Xiao*, et al. Colorimetric and fluorometric monitoring of the helix composition of collagen-like peptides at the nM level. Chemical Communications. 2016, 52, 3107-3110.

        9)Xiuxia Sun, Jun Fan, Jianxi Xiao*, et al. A graphene oxide-based FRET sensor for rapid and specific detection of unfolded collagen fragments. Biosensors and Bioelectronics. 2016, 79, 15-21.

        10)Xiuxia Sun, Jun Fan, Jianxi Xiao*, et al. A highly specific graphene platform for sensing collagen triple helix. Journal of Materials Chemistry B. 2016, 4, 1064-1069. (Hot paper)

        11)Xiuxia Sun, Songqing Liu, Jianxi Xiao*, et al. CD and NMR investigation of collagen peptides mimicking a pathological Gly-Ser mutation and a natural interruption in a similar highly charged sequence context. Protein Science. 2016, 25, 383-392.

        12)Xiuxia Sun, Yalin Chai, Jianxi Xiao*, et al. A natural interruption displays higher global stability and local conformational flexibility than a similar Gly mutation sequence in collagen mimic peptides. Biochemistry. 2015, 39, 6106-6113.

        13)Xiuxia Sun, Xiangdong Cai, Renqi Wang and Jianxi Xiao*. Immobilized trypsin on hydrophobic cellulose decorated nanoparticles shows good stability and reusability for protein digestion. Analytical Biochemistry. 2015, 477, 21-27.

     

  • (1) 国家自然科学基金面上项目(22074057), 在研, 参与

    (2) 国家自然科学基金面上项目(21775059), 在研, 参与

     

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