【基本情况】

    课题组主要从事我国传统中草药植物中具有重要生物活性和新颖结构天然化合物的发现研究工作。到目前为止，已经对数十种中草药或植物的化学成分进行了系统的分离分析，发现新化合物100多个，其中5个新颖碳骨架萜类化合物teuviscins A, euphorikanin A、crocrassin A， norcrassin A和eupulcherol A被天然产物权威评论杂志Natural Product Reports选为热点化合物。同时在药理活性方面，课题组开展了抗AD、抗肿瘤、抗菌、降糖等生物活性，特别是有关抗神经退行性疾病中药活性成分的发现及其作用机制的研究。已经发表60多篇SCI论文，包括Organic Letters, Organic Chemistry Frontiers, Journal of Natural Products， Organic & Biomolecular Chemistry, RSC Advances， Fitoterapia, Planta Medica, Tetrahedron Letters, Phytochemistry Letters等。现为教育部学位与研究生教育发展中心通讯评议专家，国家自然科学基金通讯评议专家，同时担任多个SCI杂志的审稿人。

【研究方向】

    天然产物活性成分的分离、结构鉴定和药理研究；中药抗神经退行性疾病活性及作用机制研究 

【主讲课程】

    药学专业本科生专业基础课《分析化学》（该课程为甘肃省精品课程）、《分析化学实验》

    药学专业本科生专业限选课《现代分析技术及其在药学中的应用》

    研究生专业基础课《高级天然产物化学》

【获奖情况】

    （1）2018年度，甘肃省药学发展奖一等奖

    （2）2017、2021年度，兰州大学本科毕业论文（设计）优秀指导教师

（1）Diterpenoid caesalmin C delays Aβ-induced paralysis symptoms via the DAF-16 pathway in Caenorhabditis elegans. Internatinal Journal of Molecular Sciences 2022, 23, 6871.

（2）Caesalpinbondin A, a novel diterpenoid lactone with an unprecedengted carbon skeleton from the seeds of Caesalpinia bonduc. Frontiers in Chemistry, 2022, 10, 911543.

（3）Diterpenoids and C13 Nor-Isoprenoid Identified from the Leaves and Twigs of Croton yanhuii Activating Apoptosis and Pyroptosis. Frontiers in Chemistry, 2022, 10, 861278.

（4）Diterpenoids with α-glucosidase inhibitory activities from the fruits of Vitex trifolia Linn. Fitoterapia 2022, 161, 105248

（5）Chemical constituents from the fruits of Vitex trifolia L. (Verbenaceae) and their chemotaxonomic significance. Biochemical Systematics and Ecology 2021, 97, 104305.

（6）Polyoxygenated sesquiterpenoids from Salvia castanea and their potential anti-Alzheime's disease bioactivities. Fitoterapia, 2021, 151, 104867.

（7）Triterpenoids with α-glucosidase inhibitory activities from the roots of Codonopsis pilosula var. modesta. Journal of Chemical Research 2021, 45(5-6), 635-638.

（8）Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer’s disease bioactivity. Organic & Biomolecular Chemistry 2020, 18, 76-80.

（9）Cadinane-type sesquiterpenes from the resinous exudates of Commiphora myrrha and their anti-Alzheimer's disease bioactivities. Fitoterapia 2020, 142, 104536.

（10）(±)-Neonardochinone A, a pair of enantiomeric neoligans from Nardostachys chinensis with their anti-Alzheimer’s disease activities. Phytochemistry Letters 2020, 39, 39-42.

（11）Isolation, Characterization, and Possible Anti-Alzheimer’s Disease Activities of Bisabolane-Type Sesquiterpenoid Derivatives and Phenolics from the Rhizomes of Curcuma longa. Chemistry & Biodiversity 2020, 17, e2000067.

（12）Narjatamanins A and B, a pair of novel epimers possessing a 2,3-seco-iridoid skeleton with an unusual 1,10-oxygen brigen from Nardostachys jatamansi and evaluation of their effects on worm paralysis in AD C. elegans. RSC Advances 2019, 9, 24333-24337.

（13）Four novel sesquiterpenoids with their anti-Alzheimer’s disease activity from Nardostachys chinensis. Organic & Biomolecular Chemistry 2018, 16, 9038-9045.

（14）Norcrassin A, a novel C16 tetranorditerpenoid, and bicrotonol A, an unusual dimeric labdane-typediterpenoid, from the roots of Croton crassifolius. Organic & Biomolecular Chemistry 2018, 16, 1745-1750.

（15）Three new sesquiterpene lactones from Carpesium abrotanoides. Phytochemistyr Letters 2018, 27, 154-159.

（16）Norcrocrassinone: a novel tetranorditerpenoid possessing a 6/6/5 fused ring system from Croton crassifolius. Tetrahedron Letter 2018, 59, 4028-4030.

（17）A novel spirocyclic triterpenoid and a new taraxerane triterpenoid from Teucrium viscidum. Organic Chemistry Frontiers 2017, 4(1), 42-46.

（18）Cytotoxic and antibacterial activities of iridoids and sesquiterpenoids from Valeriana jatamansi. Fitoterapia 2017, 123, 73-78.

（19）Euphorikanin A, a diterpenoid lactone with a fused 5/6/7/3 ring system from Euphorbia kansui. Organic Letters 2016, 18(12), 2844-2847.

1. 国家自然科学基金面上项目，31870324，负责人；

2. 国家自然科学基金青年基金，21102065，负责人；

3. 甘肃省自然科学基金面上项目，21JR7RA477，负责人；

4. 甘肃省自然科学基金面上项目，17JR5RA201，负责人；

5. 甘肃省中青年科技基金计划项目，1208RJYA029，负责人；

6. 兰州市科技计划项目，2018-4-61，负责人；

7. 国家重点研发计划，2018YFC1706300，参与；

8. 国家自然科学基金面上项目基金，31670350，参与；

9. 中央高校基本科研业务费3项，lzujbky-2017-198，lzujbky-2015-58，lzujbky-2012-83，负责人。